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Research Article
Non-deletion haemoglobin H disease in Papua New Guinea.
  1. A V Hill,
  2. S L Thein,
  3. B Mavo,
  4. D J Weatherall,
  5. J B Clegg
  1. Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital.

    Abstract

    Analysis of DNA from members of a Melanesian family from Papua New Guinea with haemoglobin (Hb) H disease revealed that all four alpha globin genes are intact in affected subjects. Study of restriction enzyme site and length polymorphisms and the use of oligonucleotide probes indicated that the molecular basis of this Papuan form of non-deletion Hb H disease differs from the previously described Middle Eastern and Mediterranean types.

    http://dx.doi.org/10.1136/jmg.24.12.767

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