You are here

Article Text

Article menu
Download PDFPDF
Research Article
Prevalence and genetic aspects of deaf mutism in Shanghai.
  1. D N Hu,
  2. W Q Qiu,
  3. B T Wu,
  4. L Z Fang,
  5. F Zhou,
  6. Y P Gu,
  7. Q H Zhang,
  8. J H Yan
  1. Department of Medical Genetics, Tiedao Medical College, Shanghai, China.

    Abstract

    Two hundred and eighty-five cases of congenital deaf mutism were ascertained in a population of 483,611 in Zhabei District in Shanghai. The prevalence was 0.059% (1:1697). Inherited cases accounted for 84.83% of all cases. The mode of inheritance was autosomal recessive with complete penetrance and heterogeneity (consisting of at least five different loci). The fitness was 77.63%, the coefficient of selection was 0.2237, the mutation rate was 1.119 x 10(-4) mutation/gamete, and no heterozygote advantage was proven.

    https://doi.org/10.1136/jmg.24.10.589

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.