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Paternal inheritance of translocation chromosomes in a t(X;21) patient with X linked muscular dystrophy.
  1. V M Kean,
  2. H L Macleod,
  3. M W Thompson,
  4. P N Ray,
  5. C Verellen-Dumoulin,
  6. R G Worton


    A number of DNA probes from the short arm of the X chromosome have been used to study the inheritance of the translocation chromosomes in a girl with an X; autosome translocation and muscular dystrophy. The two translocation chromosomes were found to be derived from the father's single normal X chromosome, ruling out maternal inheritance of a pre-existent mutation and enhancing the concept that the de novo translocation is responsible for the dystrophic phenotype.

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