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A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.
  1. B Wainwright,
  2. M Farrall,
  3. E Watson,
  4. R Williamson


    We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.

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