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The genetic control of phenformin 4-hydroxylation.
  1. R R Shah,
  2. D A Evans,
  3. N S Oates,
  4. J R Idle,
  5. R L Smith


    Previously published results of phenformin 4-hydroxylation in 195 unrelated white British volunteers and 87 family members of 27 randomly selected probands have been subjected to genetic analysis. The results clearly show that about 9% of this population has a genetically determined defect in carrying out this oxidation reaction. The character for the defect is inherited in a Mendelian autosomal recessive fashion. The polymorphism shows a substantial degree of dominance.

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