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A case of suspected teratogenic holoprosencephaly.
  1. M Stabile,
  2. A Bianco,
  3. S Iannuzzi,
  4. M C Buonocore,
  5. V Ventruto


    A case of holoprosencephaly is reported in which the mother was prescribed high doses of oestroprogestins during the first 5 months of the pregnancy. Investigation of the family failed to reveal any sign of physical abnormality. A normal karyotype was detected in the proband. The authors suggest that this case may shed some light on the normal and abnormal way in which embryonic fields develop.

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