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Increased frequency of lymphocytic mitotic non-disjunction in recurrent spontaneous aborters.
  1. R C Juberg,
  2. J Knops,
  3. P N Mowrey


    Hypermodal chromosomal spreads occurred significantly more frequently in lymphocytes from couples with recurrent spontaneous abortion than from comparison populations. Previously, we reported a similarly increased frequency in couples with aneuploid offspring. Considering the frequency of aneuploidy among first trimester spontaneous abortions, we suggest that there may be a sub-population of persons predisposed to non-disjunction among couples with reproductive wastage.

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