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Graves' disease and Down's syndrome
  1. A J McCulloch*,
  2. F Clark,
  3. N R Steele*
  1. *Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne
  2. Department of Medicine, Freeman Hospital, Newcastle upon Tyne.


    A case is described of severe thyrotoxicosis occurring in a patient with Down's syndrome, in which behavioural disturbance was a marked but reversible phenomenon. In addition, we report that antibodies capable of stimulating the thyroid were detectable in the sputum of both the patient and his mother.

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