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Antenatal detection of grossly distended bladder owing to absence of the urethra in a fetus with trisomy 18.
  1. N C Nevin,
  2. J Nevin,
  3. J M Dunlop,
  4. M Gray


    An ultrasonic examination revealed a grossly distended fetal abdomen. Amniocentesis at 19 weeks' gestation showed raised amniotic fluid alphafetoprotein, a second band of specific acetylcholinesterase, and a fetal karyotype 47,XY,+18. The pregnancy was terminated and the necropsy examination showed absence of the urethra, grossly distended bladder, hydroureters, and congenital heart anomalies.

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