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Hypostatic ulcers in 47,XXY Klinefelter's syndrome
  1. Marion S Verp,
  2. Joe Leigh Simpson,
  3. Alice O Martin
  1. Section of Human Genetics, Department of Obstetrics and Gynecology, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, Illinois, USA.


    Hypostatic leg ulcers, probably secondary to vascular insufficiency, were observed in two adult men with 47,XXY Klinefelter's syndrome. The association between leg ulcers and 47,XXY Klinefelter's syndrome deserves increased attention because knowledge of the association may alert clinicians to an otherwise unsuspected chromosome abnormality.

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