Article Text

Download PDFPDF

Huntington's chorea in South Wales: mutation, fertility, and genetic fitness.
  1. D A Walker,
  2. P S Harper,
  3. R G Newcombe,
  4. K Davies


    A study of mutation, biological fitness, and patterns of family building in Huntington's chorea has been carried out, based on a previously reported population study of the disorder in South Wales. No unequivocal new mutation was identified among 101 kindreds containing 418 affected persons, which supports the extreme rarity of mutation in this disorder. Increased values of fertility and fitness were found, both in relation to unaffected relatives and to the general population of the area. The proportion of unmarried persons and pattern of family building was comparable in affected and unaffected subjects, and no correlation with age at onset or mode of clinical presentation could be found.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.