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Autoimmune chronic active hepatitis in Down's syndrome
  1. Alan J McCulloch*,
  2. Paul G Ince,
  3. Pat Kendall-Taylor
  1. Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP.
  2. Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP.


    Hashimoto's thyroiditis, autoimmune adrenalitis, pernicious anaemia, and diabetes mellitus are all recognised associations with Down's syndrome. In addition chronic active hepatitis (CAH) resulting from chronic hepatitis B antigenaemia is known to occur in these patients, but an association of autoimmune CAH and Down's syndrome has not previously been described. We report a case in which Down's syndrome was associated with autoimmune CAH, Hashimoto's thyroiditis, and alopecia areata.

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    • * Currently MRC Research Fellow, Department of Clinical Biochemistry and Metabolic Medicine, Royal Victoria Infirmary, Newcastle upon Tyne.