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The mutation rate to Huntington's chorea
  1. Michael Shaw*,
  2. Adrian Caro
  1. *The Department of Biology, University of East Anglia, Norwich, Norfolk NR4 7TJ
  2. Theatre Royal Surgery, Theatre Street, Dereham, Norfolk NR19 2EN


    The problems of estimating the mutation rate to Huntington's chorea, or the proportion of new mutants among all sufferers, are discussed. The available survey data are reviewed. The prevalence of sporadic phenotypes, which include new mutations, is probably less than 2·5%. New mutants probably make up around 0·1% or less of all sufferers.

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    • Present address: Department of Biology, University of York, Heslington, Yorks YO1 5DD.

      Received for publication 7 September 1981.