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Serum gonadotrophins in Down's syndrome
  1. W A Campbell,
  2. Judith Lowther,
  3. Irene McKenzie,
  4. W H Price
  1. MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU
  2. The University Department of Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU


    Serum levels of follicle stimulating hormone (FSH) and luteinising hormone (LH) in institutionalised male patients with Down's syndrome (DS) have been found to be significantly higher than in age matched controls from the same institution. This difference is found in patients both under and over 30 years of age with respect to FSH levels, but the increase in LH levels is confined to patients with DS over 30.

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