Article Text

Download PDFPDF

An epidemiological and genetic study of facial clefting in France. I. Epidemiology and frequency in relatives.
  1. C Bonaiti,
  2. M L Briard,
  3. J Feingold,
  4. B Pavy,
  5. J Psaume,
  6. G Migne-Tufferaud,
  7. J Kaplan


    The frequencies of cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) have been estimated in France to be 0.082% and 0.035%, respectively, after exclusion of malformation syndromes. A genetic and epidemiological study has been carried out on 468 patients with CL(P) and 163 with CP. The results are given in detail and some specific points are discussed: the apparently low incidence in France, the relationship between sex ratio and abortion rates, the maternal effects, and the possibility of an association between CL(P) and CP.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.