Serum specimens from eight females and two males representing three generations of an American Negro family exhibited an α1-antitrypsin phenotype that we labelled MPclifton because of its electrophoretic mobility. The family study and examination of multiple specimens from the same subject indicated that the phenotype represented an α1-antitrypsin allele, labelled PiPclifton. The new genetic variant is not associated with deficiency of α1-antitrypsin or of trypsin inhibitory capacity in the serum.
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