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Research Article
Stable dicentric autosome, tdic (8:22)(p23:p13), in a mentally retarded girl.
  1. S H Roberts,
  2. R T Howell,
  3. K M Laurence,
  4. M E Heathcote

    Abstract

    A dicentric autosome, tdic(8:22)(p23:p13), was found in all metaphase cells examined from the peripheral blood of a mentally retarded girl. It is suggested that the centromere of chromosome 22 was inactive, allowing the dicentric to behave as a monocentric element. The involvement of acrocentric chromosomes in the stable dicentric autosomes of man is discussed.

    https://doi.org/10.1136/jmg.14.1.66

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