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A new case of haemoglobin Bucuresti in a Cuban family: further functional studies.
  1. B Colombe,
  2. M P Benitez,
  3. L Bernini,
  4. J Elien,
  5. H Wajeman,
  6. D Labie


    A new case of haemoglobin Bucuresti beta 42 (CD1) Phe yields Leu is described in a Cuban family. The functional studies confirm the results already described--a low oxygen affinity and a decreased haem-haem interaction. In addition to this, the reactivity for 2, 3 diphosphoglycerate (2, 3 DPG) was shown to be normal. The instability is mostly due to a fast rate of haemichromes formation.

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