A family of three generations has been described with an insertional type of chromosome rearrangement involving chromosomes 11 and 18[46,XX or XY, ins(11;18)(p15;q11q21)] detected by G-banding using a trypsin digestion method. Four members of this family with clinical features of 18q− have inherited the der(18) from their father and are thus deficient for (18)(q11q21). Three other family members have inherited the der(11) and thus have a duplication of the same segment [(18)(q11q21)]. Genetic marker studies on this family, show no significant segregation of any of the markers studied with either the der(11) or der(18). Eight family members had the PepA8PepA1 genotype and four of these were carrying the der(18), indicating that the PepA locus which had been previously assigned to chromosome 18, does not lie in the segment q11→q21.
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↵† Faculty of Medicine, University of Manitoba.
↵‡ Health Sciences Children's Centre.
↵** Division of Genetics (Department of Pediatrics), University of Manitoba and Health Sciences Children's Centre, Winnipeg, Manitoba, Canada.
↵* Reprint requests to: Dr J. L. Hamerton, Department of Genetics, Health Sciences Children's Centre, 685 Bannatyne Avenue, Winnipeg, Manitoba, Canada.