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Muscle ribosomal protein synthesis in normal pregnancy: implication for carrier detection in Duchenne muscular dystrophy
  1. Victor Ionasescu,
  2. Charles White,
  3. Hans Zellweger,
  4. Ruth Lewis**,
  5. Thomas W. Conway**
  1. College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA


    Muscle samples of rectus abdominis were obtained from 11 normal pregnant women 21-30 years old during elective Caesarean section and from 10 normal, non-pregnant controls of comparable age. The in-vitro amino-acid incorporation of polyribosomes extracted from the muscle homogenates of the pregnant women showed high activity for the synthesis of non-collagen protein in six cases, while control values were found in five cases. These results indicate that carrier detection in Duchenne muscular dystrophy based on increased muscle ribosomal protein synthesis cannot be done accurately during pregnancy, unless adequate values for known carriers at a comparable stage of gestation are available.

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    • Department of Pediatrics.

    • Department of Obstetrics and Gynecology.

    • ** Department of Biochemistry.

    • * This study was supported in part by the Muscular Dystrophy Associations of America, Inc, NIH Grant NS09283, USPHS Clinical Research Center MOI-FR-59, and State Services for Crippled Children, Special Project MR12, HEW, Children's Bureau, Clinical Research in Mental Retardation and Genetic Society.