Article Text

Download PDFPDF
A Kindred with Familial Cold Urticaria: Linkage Analysis
  1. H. M. G. Doeglas*,
  2. L. F. Bernini,
  3. G. R. Fraser,
  4. Erna Van Loghem,
  5. P. Meera Khan,
  6. L. E. Nyenhuis,
  7. P. L. Pearson


    Familial cold urticaria is an autosomal dominant hereditary disease of which seven pedigrees have been published, six from the USA and the present one from Holland. Onset is shortly after birth. The patients develop skin symptoms sometimes accompanied by fever, chills, joint symptoms, and oedema, approximately one half to three hours after generalized exposure to cold.

    In this paper the linkage data from the Dutch family are described; three generations containing 11 affected persons were studied in relation to 31 markers. While the data are inconclusive, they are presented here from the point of view of eventual accumulation when other families are studied in the same way.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


    • * Department of Dermatology, University Hospital, University of Groningen, Groningen, The Netherlands.

    • Institute for Anthropogenetics, University of Leiden, Leiden, The Netherlands.

    • Central Laboratory of the Blood Transfusion Service, Amsterdam, The Netherlands.