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Myoglobin in Primary Muscular Disease: I. Duchenne Muscular Dystrophy: and: II. Muscular Dystrophy of Distal Type
  1. A. E. Romero-Herrera*,
  2. H. Lehmann*,
  3. B. E. Tomlinson,
  4. J. N. Walton


    Skeletal myoglobin from two cases of muscular dystrophy, one of Duchenne muscular dystrophy, and one of muscular dystrophy of distal type, have been examined and no differences from normal human myoglobin were found. The opportunity has been taken to discuss the nature of minor fractions of myoglobin-like material which are found when human skeletal myoglobin is isolated. Those which have been observed in the present study have been artefacts and it was possible to demonstrate that they were due to deamidation of certain glutamine and asparagine residues.

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    • * Medical Research Council Abnormal Haemoglobin Unit, University of Cambridge, Department of Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2QR.

    • Department of Pathology, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE.

    • Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE.