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Preliminary Communication: Familial Accumulation of Carriers of Au Antigen
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  1. Timo Helske,
  2. H. R. Nevanlinna
  1. 1Finnish Red Cross Blood Transfusion Service, Helsinki 31, Finland

    Abstract

    The sibs and parents of 83 Au-positive blood donors were tested in order to study the possible family clustering of Au positives in a population with a low frequency of carriers of Australia (Au) antigen. Tested by counterelectrophoresis the incidence of Au antigen in the parents of Au-positive persons is 5·4% and in the sibs 17·9%, compared to 0·15% in blood donors.

    The hypothesis that the Au-carrier state is genetically determined was tested by calculating the proportion of Au-positive children in the families. The results are not inconsistent with a recessive mode of inheritance but do not allow definitive conclusions to be drawn.

    http://dx.doi.org/10.1136/jmg.10.3.270

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