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Origin of 48,XXXY: The Evidence of the Xg Blood Groups
  1. R. A. Pfeiffer*,
  2. Ruth Sanger


    A third family is reported in which the Xg groups give information about the origin of an XXXY member: successive non-disjunction at the first and second paternal meiotic divisions is much the most likely cause. In the two previous informative families successive non-disjunction at maternal meiotic divisions was the most likely cause. An enquiry showed the average age of 29 fathers at the birth of XXXY sons to be 32-41 years.

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    • * Institut für Humangenetik der Universität Münster, Federal Republic of Germany.

    • MRC Blood Group Unit, Lister Institute, London SW1W 8RH.