Article Text

Download PDFPDF
Segregation Ratios in Alport's Syndrome
  1. Elizabeth MacNeill*,
  2. Richard F. Shaw
  1. Departments of Biology and Pediatrics and Preventive Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

    Abstract

    Pooled data of 35 pedigrees for Alport's syndrome were analysed. Affected to normal ratios among the offspring of heterozgyous fathers and mothers were tabulated. Offspring of heterozygous mothers were tabulated separately where the mother showed symptoms of the disease and where she was asymptomatic. Three current theories on the inheritance of Alport's syndrome are considered and discussed. Each theory fails to account fully for the known facts. A non-chromosomal agent has not yet been excluded for this intriguing disease.

    Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Footnotes

    • * Present address: Apt# 1305, Cabot House, 500 King's Road, Sydney, Nova Scotia, Canada.

    • Present address: Department of Epidemiology, University of Sherbrooke, Sherbrooke, Quebec, Canada.