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Segregation Ratios in Alport's Syndrome
  1. Elizabeth MacNeill*,
  2. Richard F. Shaw
  1. Departments of Biology and Pediatrics and Preventive Medicine, Dalhousie University, Halifax, Nova Scotia, Canada


    Pooled data of 35 pedigrees for Alport's syndrome were analysed. Affected to normal ratios among the offspring of heterozgyous fathers and mothers were tabulated. Offspring of heterozygous mothers were tabulated separately where the mother showed symptoms of the disease and where she was asymptomatic. Three current theories on the inheritance of Alport's syndrome are considered and discussed. Each theory fails to account fully for the known facts. A non-chromosomal agent has not yet been excluded for this intriguing disease.

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    • * Present address: Apt# 1305, Cabot House, 500 King's Road, Sydney, Nova Scotia, Canada.

    • Present address: Department of Epidemiology, University of Sherbrooke, Sherbrooke, Quebec, Canada.