Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Prostate cancer is the most common cancer in men in Europe and the United States. The
genetic heritability of prostate cancer is contributed to by both rarely occurring genetic …

The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data …

Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple
competing subclones within a single primary tumour,,,. This evolutionary process culminates …

Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …

Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant
Metastasis, and Poor Survival Outcomes in Prostate Cancer - PMC Back to Top Skip to main …

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify …

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed
countries. To identify common PrCa susceptibility alleles, we previously conducted a …