Interleukin-1 (IL-1) is primarily an inflammatory cytokine, although it is capable of mediating
a wide variety of effects on many different cell types. Nearly every known signal transduction …

Cancer research in recent years has immensely benefited from the development of novel
technologies that enable scientists to perform detailed investigations of genomes …

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …

Background Few biomarkers of ovarian cancer prognosis have been established, partly
because subtype-specific associations might be obscured in studies combining all …

Genome-wide association studies (GWAS) have identified four susceptibility loci for
epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome …

OBJECTIVES.: Folate receptor α (FRα) is a folate-binding protein overexpressed on ovarian
and several other epithelial malignancies that can be used as a target for imaging and …

Clinical outcomes in ovarian cancer are heterogeneous even when considering common
features such as stage, response to therapy, and grade. This disparity in outcomes warrants …

The breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a
single tumor-initiating cell with stem-like properties, but the source of these cells is unclear …

Purpose: PD-0332991 is a selective inhibitor of the CDK4/6 kinases with the ability to block
retinoblastoma (Rb) phosphorylation in the low nanomolar range. Here we investigate the …

Molecular classification of high-grade serous ovarian cancer (HGSOC) using transcriptional
profiling has proven to be complex and difficult to validate across studies. We determined …