INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Abstract The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide
association study of late-onset Alzheimer disease using a three-stage design consisting of a …

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in
which the risk of disease is influenced by complex genetic and environmental contributions …

Genome-wide association studies (GWAS) have identified several risk variants for late-onset
Alzheimer's disease (LOAD),. These common variants have replicable but small effects on …

Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More
than 20 common markers have been identified, which are associated with AD. Recently …

Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous
clinical manifestations. A polymorphism in the STAT4 gene has recently been established as …

Systemic lupus erythematosus (SLE) is a clinically heterogeneous, systemic autoimmune
disease characterized by autoantibody formation. Previously published genome-wide …

Importance BecauseAPOElocus variants contribute to risk of late-onset Alzheimer disease
(LOAD) and to differences in age at onset (AAO), it is important to know whether other …

Abstract Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites
of European ancestry, but the genetic architecture of AD among other populations is less …

Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex
deposition and inflammation. Lupus nephritis demonstrates familial aggregation and …