Background Fabry's disease, an X-linked disorder of lysosomal α-galactosidase deficiency,
leads to substrate accumulation in multiple organs. Migalastat, an oral pharmacologic …

Background Fabry disease is an X-linked lysosomal storage disorder caused by GLA
mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulation of lysosomal …

Purpose Outcomes in patients with Fabry disease receiving migalastat during the phase 3
FACETS trial (NCT00925301) were evaluated by phenotype. Methods Data were evaluated …

We have compared the expression and localization of neuronal microtubule-associated
proteins (MAPs) MAP5, MAP2, and tau in the adult rat olfactory system and cerebral cortex …

We examined the impact of FDA's 2008 guidelines for addressing cardiovascular risks of
new therapies for type 2 diabetes on clinical trials. We focused on the new class of incretin …

MAP5 is a microtubule-associated protein that in rat and quail is more abundant in the
developing than in the adult brain. Previous studies in our laboratory have shown that MAP5 …

• While different allantoin-containing preparations have been used clinically to study its
therapeutic effects in wound healing, its mechanisms of action are not known with certainty• …

Besipirdine hydrochloride is a novel compound with cholinergic and adrenergic activity
being investigated as a treatment for Alzheimer's disease (AD). The pharmacodynamics of …

We compared the clinical trial transparency practices of US/European pharma by analyzing
the publicly-accessible clinical trial results databases of major drugs (doripenem …

In his studies of the cerebellum, Ramón y Cajal (1888, 1960) noted, with characteristic
clarity, the major features of morphogenesis in the various cell types. Many of his …