1Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University, School of
Medicine, Cardiff, UK; 2Department of Gastroenterology, Prince Charles Hospital, Merthyr …

Background Screening of patients with familial adenomatous polyposis (FAP) have led to a
substantial reduction in mortality due to colorectal cancer (CRC). Recent guidelines suggest …

Colorectal cancer (CRC) has a very high incidence in the western world. Data from registries
in the Middle East showed that the incidence of CRC is relatively low in these countries …

Background Lynch syndrome (LS), the most common inherited form of colorectal cancer
(CRC), is responsible for 3% of all cases of CRC. LS is caused by a mismatch repair gene …

Familial adenomatous polyposis (FAP) is a dominantly inherited syndrome caused by
germline mutations in the APC gene and characterized by the development of multiple …

Background: Familial adenomatous polyposis (FAP) is characterized by the development of
hundreds of colorectal adenomas in the second decade of life, and prophylactic colectomy is …

Abstract Objectives: In 2014, a population-screening program using immuno-faecal occult
blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to …

Background Constitutional mismatch repair deficiency (CMMRD) is a rare autosomal
recessively inherited syndrome that is caused by biallelic pathogenic variants of the …

Barrett's oesophagus (BE) has been associated with an increased risk of both colorectal
adenomas and colorectal cancer. A recent investigation reported a high frequency of BE in …

Erratum to: A new hereditary colorectal cancer network in the Middle East and eastern
Mediterranean countries to improve care for high-risk families - PMC Back to Top Skip to main …