User profiles for "author:Thomas Klockgether"

Thomas Klockgether

Verified email at uni-bonn.de
Cited by 47730

Consensus statement on the diagnosis of multiple system atrophy

S Gilman, P Low, N Quinn, A Albanese… - Clinical autonomic …, 1998 - Springer
We report the results of a consensus conference on the diagnosis of multiple system atrophy
(MSA). We describe the clinical features of the disease, which include four domains …

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

M Sastre, T Klockgether, MT Heneka - International journal of …, 2006 - Elsevier
There is compelling evidence that Alzheimer's disease (AD) amyloid-β (Aβ) deposition is
associated with a local inflammatory response, which is initiated by the activation of …

Spinocerebellar ataxia

T Klockgether, C Mariotti, HL Paulson - Nature reviews Disease primers, 2019 - nature.com
The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …

Second consensus statement on the diagnosis of multiple system atrophy

S Gilman, GK Wenning, PA Low, DJ Brooks… - Neurology, 2008 - AAN Enterprises
Background: A consensus conference on multiple system atrophy (MSA) in 1998
established criteria for diagnosis that have been accepted widely. Since then, clinical …

[HTML][HTML] The natural history of multiple system atrophy: a prospective European cohort study

GK Wenning, F Geser, F Krismer, K Seppi… - The lancet …, 2013 - thelancet.com
Background Multiple system atrophy (MSA) is a fatal and still poorly understood
degenerative movement disorder that is characterised by autonomic failure, cerebellar …

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

MT Heneka, M Sastre, L Dumitrescu-Ozimek, A Hanke… - Brain, 2005 - academic.oup.com
Neuritic plaques in the brain of Alzheimer's disease patients are characterized by β-amyloid
deposits associated with a glia-mediated inflammatory response. Non-steroidal anti …

[PDF][PDF] Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy

H Pels, IGH Schmidt-Wolf, A Glasmacher… - Journal of Clinical …, 2003 - academia.edu
Purpose: To evaluate response rate, response duration, overall survival (OS), and toxicity in
primary CNS lymphoma (PCNSL) after systemic and intraventricular chemotherapy with …

Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

M Sastre, I Dewachter, S Rossner… - Proceedings of the …, 2006 - National Acad Sciences
Epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs)
decrease the risk for Alzheimer's disease (AD). Certain NSAIDs can activate the peroxisome …

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan… - Nature, 2011 - nature.com
Machado–Joseph disease (MJD; also called spinocerebellar ataxia type 3) is a dominantly
inherited late-onset neurodegenerative disorder caused by expansion of polyglutamine …

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein …

M Sastre, I Dewachter, GE Landreth… - Journal of …, 2003 - Soc Neuroscience
Long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk for
Alzheimer's disease (AD). To determine the mechanisms by which inflammation affects AD …