User profiles for "author:Serban Radian"

Serban Radian

C. Davila University of Medicine and Pharmacy, Bucharest, Romania
Verified email at parhon.ro
Cited by 632

FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome

R Attaoua, SA El Mkadem, S Radian, S Fica… - Biochemical and …, 2008 - Elsevier
The FTO (Fat mass and obesity associated) locus has recently been associated with obesity
and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic …

The value of an acute octreotide suppression test in predicting long‐term responses to depot somatostatin analogues in patients with active acromegaly

N Karavitaki, I Botusan, S Radian… - Clinical …, 2005 - Wiley Online Library
Background The long‐acting depot somatostatin analogues [octreotide LAR (LAR) and
lanreotide (LAN)] are among the most effective available medical therapies for acromegaly …

Increased Population Risk of AIP‐Related Acromegaly and Gigantism in Ireland

S Radian, Y Diekmann, P Gabrovska… - Human …, 2017 - Wiley Online Library
The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304*(or p. R304*;
NM_003977. 3: c. 910C> T, p. Arg304Ter) identified in Northern Ireland (NI) predisposes to …

Biochemical hyperandrogenism is associated with metabolic syndrome independently of adiposity and insulin resistance in Romanian polycystic ovary syndrome …

A Albu, S Radian, S Fica, CG Barbu - Endocrine, 2015 - Springer
The aim of the study was to determine whether Romanian polycystic ovary syndrome
(PCOS) patients have an increased prevalence of metabolic syndrome (MetS) and to study …

AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience

C Ramírez-Rentería, LC Hernández-Ramírez… - Endocrine, 2016 - Springer
Although aryl hydrocarbon receptor-interacting protein (AIP) mutations are rare in sporadic
acromegaly, their prevalence among young patients is nonnegligible. The objectives of this …

In vivo bioassay to test the pathogenicity of missense human AIP variants

ED Aflorei, B Klapholz, C Chen, S Radian… - Journal of Medical …, 2018 - jmg.bmj.com
Background Heterozygous germline loss-of-function mutations in the aryl hydrocarbon
receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The …

In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism

R Salvatori, S Radian, Y Diekmann… - European journal of …, 2017 - academic.oup.com
Objective Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are
associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated …

Acromegaly treatment in Romania. How close are we to disease control?

DA Niculescu, IF Baciu, C Capatina… - Endokrynologia …, 2017 - journals.viamedica.pl
Abstract Introduction: In Romania, no nationwide data for acromegaly treatment and control
rate are available. Our objective was to assess the acromegaly control rate in a tertiary …

[HTML][HTML] Association of insulin receptor genetic variants with polycystic ovary syndrome in a population of women from Central Europe

FA Hanzu, S Radian, R Attaoua, S Ait-El-Mkadem… - Fertility and sterility, 2010 - Elsevier
To assess the role of the insulin receptor gene in polycystic ovary syndrome (PCOS) we
performed a case-control study in a female population (n= 226) from Central Europe by …

[HTML][HTML] High mortality risk among women with acromegaly still persists

S Găloiu, ID Toma, DI Tănasie, A Bărbulescu… - Frontiers in …, 2024 - frontiersin.org
Introduction The mortality ratio in patients with acromegaly has improved over the last few
decades. We aimed to determine the mortality rate and correlated factors in patients with …