Pathways for degradation of connexins and gap junctions
VM Berthoud, PJ Minogue, JG Laing… - Cardiovascular …, 2004 - academic.oup.com
Gap junctional proteins, connexins, and gap junctional plaques are short-lived. Three
pathways for their degradation have been proposed:(1) misfolded/abnormally oligomerized …
pathways for their degradation have been proposed:(1) misfolded/abnormally oligomerized …
[HTML][HTML] Connexin mutants compromise the lens circulation and cause cataracts through biomineralization
VM Berthoud, J Gao, PJ Minogue, O Jara… - International Journal of …, 2020 - mdpi.com
Gap junction-mediated intercellular communication facilitates the circulation of ions, small
molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap …
molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap …
Autophagy: a pathway that contributes to connexin degradation
A Lichtenstein, PJ Minogue, EC Beyer… - Journal of cell …, 2011 - journals.biologists.com
The function of connexins, which form gap junctions, can be rapidly modulated by
degradation, because they have half-lives of only a few hours. Autophagy is a degradation …
degradation, because they have half-lives of only a few hours. Autophagy is a degradation …
[HTML][HTML] Roles and regulation of lens epithelial cell connexins
VM Berthoud, PJ Minogue, P Osmolak, JI Snabb… - FEBS letters, 2014 - Elsevier
The avascular lens of the eye is covered anteriorly by an epithelium containing nucleated,
metabolically active cells. This epithelium contains the first lens cells to encounter noxious …
metabolically active cells. This epithelium contains the first lens cells to encounter noxious …
[HTML][HTML] A mutant connexin50 with enhanced hemichannel function leads to cell death
PJ Minogue, JJ Tong, A Arora… - … & visual science, 2009 - jov.arvojournals.org
Purpose.: To determine the consequences of expression of a novel connexin50 (CX50)
mutant identified in a child with congenital total cataracts. Methods.: The GJA8 gene was …
mutant identified in a child with congenital total cataracts. Methods.: The GJA8 gene was …
Loss of function and impaired degradation of a cataract-associated mutant connexin50
VM Berthoud, PJ Minogue, J Guo… - European journal of cell …, 2003 - Elsevier
A mutant human connexin50 (hCx50), hCx50P88S, has been linked to cataracts inherited as
an autosomal dominant trait. The functional, biochemical and cellular behavior of wild-type …
an autosomal dominant trait. The functional, biochemical and cellular behavior of wild-type …
[HTML][HTML] Connexin mutants cause cataracts through deposition of apatite
PJ Minogue, AJ Sommer, JC Williams Jr… - Frontiers in Cell and …, 2022 - frontiersin.org
Cataracts are lens opacities that are among the most common causes of blindness. It is
commonly believed that cataracts develop through the accumulation of damage to lens …
commonly believed that cataracts develop through the accumulation of damage to lens …
An intact connexin N-terminus is required for function but not gap junction formation
JW Kyle, PJ Minogue, BC Thomas… - Journal of cell …, 2008 - journals.biologists.com
The cytoplasmic N-termini of connexins have been implicated in protein trafficking,
oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 …
oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 …
[HTML][HTML] An aberrant sequence in a connexin46 mutant underlies congenital cataracts
An increasing number of diseases have been mapped to genes coding for ion channel
proteins, including the gap junction proteins, connexins. Here, we report on the identification …
proteins, including the gap junction proteins, connexins. Here, we report on the identification …
[HTML][HTML] A crystallin mutant cataract with mineral deposits
PJ Minogue, J Gao, RT Mathias, JC Williams… - Journal of Biological …, 2023 - ASBMB
Connexin mutant mice develop cataracts containing calcium precipitates. To test whether
pathologic mineralization is a general mechanism contributing to the disease, we …
pathologic mineralization is a general mechanism contributing to the disease, we …