Pathways for degradation of connexins and gap junctions

VM Berthoud, PJ Minogue, JG Laing… - Cardiovascular …, 2004 - academic.oup.com
Gap junctional proteins, connexins, and gap junctional plaques are short-lived. Three
pathways for their degradation have been proposed:(1) misfolded/abnormally oligomerized …

[HTML][HTML] Connexin mutants compromise the lens circulation and cause cataracts through biomineralization

VM Berthoud, J Gao, PJ Minogue, O Jara… - International Journal of …, 2020 - mdpi.com
Gap junction-mediated intercellular communication facilitates the circulation of ions, small
molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap …

Autophagy: a pathway that contributes to connexin degradation

A Lichtenstein, PJ Minogue, EC Beyer… - Journal of cell …, 2011 - journals.biologists.com
The function of connexins, which form gap junctions, can be rapidly modulated by
degradation, because they have half-lives of only a few hours. Autophagy is a degradation …

[HTML][HTML] Roles and regulation of lens epithelial cell connexins

VM Berthoud, PJ Minogue, P Osmolak, JI Snabb… - FEBS letters, 2014 - Elsevier
The avascular lens of the eye is covered anteriorly by an epithelium containing nucleated,
metabolically active cells. This epithelium contains the first lens cells to encounter noxious …

[HTML][HTML] A mutant connexin50 with enhanced hemichannel function leads to cell death

PJ Minogue, JJ Tong, A Arora… - … & visual science, 2009 - jov.arvojournals.org
Purpose.: To determine the consequences of expression of a novel connexin50 (CX50)
mutant identified in a child with congenital total cataracts. Methods.: The GJA8 gene was …

Loss of function and impaired degradation of a cataract-associated mutant connexin50

VM Berthoud, PJ Minogue, J Guo… - European journal of cell …, 2003 - Elsevier
A mutant human connexin50 (hCx50), hCx50P88S, has been linked to cataracts inherited as
an autosomal dominant trait. The functional, biochemical and cellular behavior of wild-type …

[HTML][HTML] Connexin mutants cause cataracts through deposition of apatite

PJ Minogue, AJ Sommer, JC Williams Jr… - Frontiers in Cell and …, 2022 - frontiersin.org
Cataracts are lens opacities that are among the most common causes of blindness. It is
commonly believed that cataracts develop through the accumulation of damage to lens …

An intact connexin N-terminus is required for function but not gap junction formation

JW Kyle, PJ Minogue, BC Thomas… - Journal of cell …, 2008 - journals.biologists.com
The cytoplasmic N-termini of connexins have been implicated in protein trafficking,
oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 …

[HTML][HTML] An aberrant sequence in a connexin46 mutant underlies congenital cataracts

PJ Minogue, X Liu, L Ebihara, EC Beyer… - Journal of Biological …, 2005 - ASBMB
An increasing number of diseases have been mapped to genes coding for ion channel
proteins, including the gap junction proteins, connexins. Here, we report on the identification …

[HTML][HTML] A crystallin mutant cataract with mineral deposits

PJ Minogue, J Gao, RT Mathias, JC Williams… - Journal of Biological …, 2023 - ASBMB
Connexin mutant mice develop cataracts containing calcium precipitates. To test whether
pathologic mineralization is a general mechanism contributing to the disease, we …