Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers
Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …
Association analysis identifies 65 new breast cancer risk loci
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
[PDF][PDF] Polygenic risk scores for prediction of breast cancer and breast cancer subtypes
N Mavaddat, K Michailidou, J Dennis, M Lush… - The American Journal of …, 2019 - cell.com
Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …
[HTML][HTML] Cancer risks associated with germline PALB2 pathogenic variants: an international study of 524 families
X Yang, G Leslie, A Doroszuk, S Schneider… - Journal of clinical …, 2020 - ncbi.nlm.nih.gov
PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and
to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers …
to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers …
[HTML][HTML] Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study
Background Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2,
early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) …
early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) …
Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands
CJM de Blok, CM Wiepjes, NM Nota, K van Engelen… - Bmj, 2019 - bmj.com
Objective To investigate the incidence and characteristics of breast cancer in transgender
people in the Netherlands compared with the general Dutch population. Design …
people in the Netherlands compared with the general Dutch population. Design …
[HTML][HTML] Age-and tumor subtype–specific breast cancer risk estimates for CHEK2* 1100delC carriers
MK Schmidt, F Hogervorst, R Van Hien… - Journal of clinical …, 2016 - ncbi.nlm.nih.gov
Purpose CHEK2* 1100delC is a well-established breast cancer risk variant that is most
prevalent in European populations; however, there are limited data on risk of breast cancer …
prevalent in European populations; however, there are limited data on risk of breast cancer …
Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations
G Fehringer, P Kraft, PD Pharoah, RA Eeles… - Cancer research, 2016 - AACR
Identifying genetic variants with pleiotropic associations can uncover common pathways
influencing multiple cancers. We took a two-stage approach to conduct genome-wide …
influencing multiple cancers. We took a two-stage approach to conduct genome-wide …
CHEK2* 1100delC homozygosity is associated with a high breast cancer risk in women
MA Adank, MA Jonker, I Kluijt, SE van Mil… - Journal of medical …, 2011 - jmg.bmj.com
Background Mutations in the CHEK2 gene confer a moderately increased breast cancer risk.
The risk for female carriers of the CHEK2* 1100delC mutation is twofold increased. Breast …
The risk for female carriers of the CHEK2* 1100delC mutation is twofold increased. Breast …