[HTML][HTML] Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice
Gene therapy by use of integrating vectors carrying therapeutic transgene sequences offers
the potential for a permanent cure of genetic diseases by stable vector insertion into the …
the potential for a permanent cure of genetic diseases by stable vector insertion into the …
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum
F Abbaszadeh, PH Clingen, CF Arlett… - Journal of medical …, 2010 - jmg.bmj.com
Background Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic
lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising …
lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising …
[HTML][HTML] Relative proximity of chromosome territories influences chromosome exchange partners in radiation-induced chromosome rearrangements in primary human …
It is well established that chromosomes exist in discrete territories (CTs) in interphase and
are positioned in a cell-type specific probabilistic manner. The relative localisation of …
are positioned in a cell-type specific probabilistic manner. The relative localisation of …
[HTML][HTML] The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis
Genotoxicity models are extremely important to assess retroviral vector biosafety before
gene therapy. We have developed an in utero model that demonstrates that hepatocellular …
gene therapy. We have developed an in utero model that demonstrates that hepatocellular …
Reduced chromosome aberration complexity in normal human bronchial epithelial cells exposed to low-LET γ-rays and high-LET α-particles
Purpose: Cells of the lung are at risk from exposure to low and moderate doses of ionizing
radiation from a range of environmental and medical sources. To help assess human health …
radiation from a range of environmental and medical sources. To help assess human health …
[HTML][HTML] Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature
R Condiotti, D Goldenberg, H Giladi… - Molecular Therapy, 2014 - cell.com
Lentiviral vectors are widely used in basic research and clinical applications for gene
transfer and long-term expression; however, safety issues have not yet been completely …
transfer and long-term expression; however, safety issues have not yet been completely …
Corrigendum to “Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice”
The authors regret that in Table 2 on page 768, one of the insertion sites of the SMART 2
provirus vector identified using LAM-PCR as present on chromosome 5 positioned 32374 bp …
provirus vector identified using LAM-PCR as present on chromosome 5 positioned 32374 bp …
The role of acyl carrier protein in strawberry fruit ripening
M Themis - 2000 - etheses.dur.ac.uk
Strawberry (Fragaria ananassa) is an economically important soft fruit that is highly valued
as a fresh product and flavouring. During ripening, strawberry fruits undergo a number of …
as a fresh product and flavouring. During ripening, strawberry fruits undergo a number of …
827. Oncogenesis Following Delivery of Lentiviral Vectors to Fetal and Neonatal Mice
[Srinivasakumar and Schuening (2000) J. Virol. 74: 6659-6668]. The promoters expressed
transgenes at high levels in hematopoietic cells, as has been previously shown …
transgenes at high levels in hematopoietic cells, as has been previously shown …
[CITATION][C] 394. Oncogenesis Following Delivery of a Non-Primate Lentiviral Gene Therapy Vector to Fetal Mice
394. Oncogenesis Following Delivery of a Non-Primate Lentiviral Gene Therapy Vector to
Fetal Mice × Close The Infona portal uses cookies, ie strings of text saved by a browser on the …
Fetal Mice × Close The Infona portal uses cookies, ie strings of text saved by a browser on the …