Understanding the molecular mechanisms of the multifaceted IL‐10‐mediated anti‐inflammatory response: lessons from neutrophils

F Bazzoni, N Tamassia, M Rossato… - European journal of …, 2010 - Wiley Online Library
Abstract Analysis of the molecular mechanisms governing the ability of IL‐10 to keep
inflammation under control has highlighted the existence of a great degree of plasticity and …

The role of genetics and epigenetics in the pathogenesis of systemic sclerosis

JCA Broen, TRDJ Radstake, M Rossato - Nature Reviews …, 2014 - nature.com
Systemic sclerosis (SSc) is a complex autoimmune disease of unclear aetiology. A multitude
of genetic studies, ranging from candidate-gene studies to genome-wide association …

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

F Bazzoni, M Rossato, M Fabbri… - Proceedings of the …, 2009 - National Acad Sciences
Inflammation involves a coordinated, sequential, and self limiting sequence of events
controlled by positive and negative regulatory mechanisms. Recent studies have shown that …

Negative regulation of Toll-like receptor 4 signaling by IL-10–dependent microRNA-146b

G Curtale, M Mirolo, TA Renzi… - Proceedings of the …, 2013 - National Acad Sciences
Toll-like receptors (TLRs) play key roles in detecting pathogens and initiating inflammatory
responses that, subsequently, prime specific adaptive responses. Several mechanisms …

IL-10–induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

M Rossato, G Curtale, N Tamassia… - Proceedings of the …, 2012 - National Acad Sciences
IL-10 is a potent anti-inflammatory molecule that, in phagocytes, negatively targets cytokine
expression at transcriptional and posttranscriptional levels. Posttranscriptional checkpoints …

Activation of an immunoregulatory and antiviral gene expression program in poly (I: C)-transfected human neutrophils

N Tamassia, V Le Moigne, M Rossato… - The Journal of …, 2008 - journals.aai.org
Neutrophils, historically known for their involvement in acute inflammation, are also targets
for infection by many different DNA and RNA viruses. However, the mechanisms by which …

[HTML][HTML] A rapid and accurate MinION-based workflow for tracking species biodiversity in the field

S Maestri, E Cosentino, M Paterno, H Freitag… - Genes, 2019 - mdpi.com
Genetic markers (DNA barcodes) are often used to support and confirm species
identification. Barcode sequences can be generated in the field using portable systems …

[HTML][HTML] On site DNA barcoding by nanopore sequencing

M Menegon, C Cantaloni, A Rodriguez-Prieto… - PLoS …, 2017 - journals.plos.org
Biodiversity research is becoming increasingly dependent on genomics, which allows the
unprecedented digitization and understanding of the planet's biological heritage. The use of …

[HTML][HTML] Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils

M Zimmermann, FB Aguilera, M Castellucci… - Nature …, 2015 - nature.com
Controversy currently exists about the ability of human neutrophils to produce IL-6. Here, we
show that the chromatin organization of the IL-6 genomic locus in human neutrophils is …

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia

S Audia, M Rossato, K Santegoets… - Blood, The Journal …, 2014 - ashpublications.org
Antiplatelet-antibody-producing B cells play a key role in immune thrombocytopenia (ITP)
pathogenesis; however, little is known about T-cell dysregulations that support B-cell …