Understanding the molecular mechanisms of the multifaceted IL‐10‐mediated anti‐inflammatory response: lessons from neutrophils
F Bazzoni, N Tamassia, M Rossato… - European journal of …, 2010 - Wiley Online Library
Abstract Analysis of the molecular mechanisms governing the ability of IL‐10 to keep
inflammation under control has highlighted the existence of a great degree of plasticity and …
inflammation under control has highlighted the existence of a great degree of plasticity and …
The role of genetics and epigenetics in the pathogenesis of systemic sclerosis
JCA Broen, TRDJ Radstake, M Rossato - Nature Reviews …, 2014 - nature.com
Systemic sclerosis (SSc) is a complex autoimmune disease of unclear aetiology. A multitude
of genetic studies, ranging from candidate-gene studies to genome-wide association …
of genetic studies, ranging from candidate-gene studies to genome-wide association …
Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
Inflammation involves a coordinated, sequential, and self limiting sequence of events
controlled by positive and negative regulatory mechanisms. Recent studies have shown that …
controlled by positive and negative regulatory mechanisms. Recent studies have shown that …
Negative regulation of Toll-like receptor 4 signaling by IL-10–dependent microRNA-146b
G Curtale, M Mirolo, TA Renzi… - Proceedings of the …, 2013 - National Acad Sciences
Toll-like receptors (TLRs) play key roles in detecting pathogens and initiating inflammatory
responses that, subsequently, prime specific adaptive responses. Several mechanisms …
responses that, subsequently, prime specific adaptive responses. Several mechanisms …
IL-10–induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes
M Rossato, G Curtale, N Tamassia… - Proceedings of the …, 2012 - National Acad Sciences
IL-10 is a potent anti-inflammatory molecule that, in phagocytes, negatively targets cytokine
expression at transcriptional and posttranscriptional levels. Posttranscriptional checkpoints …
expression at transcriptional and posttranscriptional levels. Posttranscriptional checkpoints …
Activation of an immunoregulatory and antiviral gene expression program in poly (I: C)-transfected human neutrophils
N Tamassia, V Le Moigne, M Rossato… - The Journal of …, 2008 - journals.aai.org
Neutrophils, historically known for their involvement in acute inflammation, are also targets
for infection by many different DNA and RNA viruses. However, the mechanisms by which …
for infection by many different DNA and RNA viruses. However, the mechanisms by which …
[HTML][HTML] A rapid and accurate MinION-based workflow for tracking species biodiversity in the field
Genetic markers (DNA barcodes) are often used to support and confirm species
identification. Barcode sequences can be generated in the field using portable systems …
identification. Barcode sequences can be generated in the field using portable systems …
[HTML][HTML] On site DNA barcoding by nanopore sequencing
M Menegon, C Cantaloni, A Rodriguez-Prieto… - PLoS …, 2017 - journals.plos.org
Biodiversity research is becoming increasingly dependent on genomics, which allows the
unprecedented digitization and understanding of the planet's biological heritage. The use of …
unprecedented digitization and understanding of the planet's biological heritage. The use of …
[HTML][HTML] Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils
M Zimmermann, FB Aguilera, M Castellucci… - Nature …, 2015 - nature.com
Controversy currently exists about the ability of human neutrophils to produce IL-6. Here, we
show that the chromatin organization of the IL-6 genomic locus in human neutrophils is …
show that the chromatin organization of the IL-6 genomic locus in human neutrophils is …
Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia
S Audia, M Rossato, K Santegoets… - Blood, The Journal …, 2014 - ashpublications.org
Antiplatelet-antibody-producing B cells play a key role in immune thrombocytopenia (ITP)
pathogenesis; however, little is known about T-cell dysregulations that support B-cell …
pathogenesis; however, little is known about T-cell dysregulations that support B-cell …