Effect of aspirin and NSAIDs on risk and survival from colorectal cancer
FVN Din, E Theodoratou, SM Farrington, A Tenesa… - Gut, 2010 - gut.bmj.com
Background Previous studies have shown that aspirin and other non-steroidal anti-
inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest …
inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest …
Educating health-care professionals about genetics and genomics
AE Guttmacher, ME Porteous, JD McInerney - Nature Reviews Genetics, 2007 - nature.com
To biomedical researchers, this is the'genome era'. Advances in genetics and genomics
such as the sequence of the human genome, the human haplotype map, open access …
such as the sequence of the human genome, the human haplotype map, open access …
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
KA McAllister, KM Grogg, DW Johnson, CJ Gallione… - Nature …, 1994 - nature.com
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder
characterized by multisystemic vascular dysplasia and recurrent haemorrhage. Linkage for …
characterized by multisystemic vascular dysplasia and recurrent haemorrhage. Linkage for …
Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE
N Mavaddat, S Peock, D Frost, S Ellis… - JNCI: Journal of the …, 2013 - academic.oup.com
Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …
[HTML][HTML] Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer
E Castro, C Goh, D Olmos, E Saunders… - Journal of Clinical …, 2013 - ncbi.nlm.nih.gov
Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant
Metastasis, and Poor Survival Outcomes in Prostate Cancer - PMC Back to Top Skip to main …
Metastasis, and Poor Survival Outcomes in Prostate Cancer - PMC Back to Top Skip to main …
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
A Tenesa, SM Farrington, JGD Prendergast… - Nature …, 2008 - nature.com
In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer
Importance Limited information about the relationship between specific mutations
inBRCA1orBRCA2 (BRCA1/2) and cancer risk exists. Objective To identify mutation-specific …
inBRCA1orBRCA2 (BRCA1/2) and cancer risk exists. Objective To identify mutation-specific …
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
L Carvajal-Carmona, K Howarth, E Jaeger, SL Spain… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly influence the risk of developing colorectal cancer (CRC). To enhance …
variants modestly influence the risk of developing colorectal cancer (CRC). To enhance …
[HTML][HTML] Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer
RA Barnetson, A Tenesa, SM Farrington… - New England journal …, 2006 - Mass Medical Soc
Background The identification of mutations in germ-line DNA mismatch-repair genes at the
time of diagnosis of colorectal cancer is important in the management of the disease …
time of diagnosis of colorectal cancer is important in the management of the disease …
Effect of BRCA mutations on metastatic relapse and cause-specific survival after radical treatment for localised prostate cancer
E Castro, C Goh, D Leongamornlert, E Saunders… - European urology, 2015 - Elsevier
Background Germline BRCA mutations are associated with worse prostate cancer (PCa)
outcomes; however, the most appropriate management for mutation carriers has not yet …
outcomes; however, the most appropriate management for mutation carriers has not yet …