Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

K Berer, LA Gerdes, E Cekanaviciute… - Proceedings of the …, 2017 - National Acad Sciences
There is emerging evidence that the commensal microbiota has a role in the pathogenesis
of multiple sclerosis (MS), a putative autoimmune disease of the CNS. Here, we compared …

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

X Zhou, R Baumann, X Gao, M Mendoza, S Singh… - Cell, 2022 - cell.com
Changes in gut microbiota have been associated with several diseases. Here, the
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …

Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis

M Spadaro, LA Gerdes, M Krumbholz… - Neurology …, 2016 - AAN Enterprises
Objectives: To evaluate the presence of antibodies to conformation-intact myelin
oligodendrocyte glycoprotein (MOG) in a subgroup of adult patients with clinically definite …

Histopathology and clinical course of MOG‐antibody‐associated encephalomyelitis

M Spadaro, LA Gerdes, MC Mayer… - Annals of clinical …, 2015 - Wiley Online Library
We present histological, MRI, and clinical features of an adult patient with relapsing
encephalomyelitis and antibodies against myelin oligodendrocyte glycoprotein (MOG) …

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

M Spadaro, S Winklmeier, E Beltrán… - Annals of …, 2018 - Wiley Online Library
Objective Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a
proportion of patients with inflammatory demyelinating diseases of the central nervous …

[HTML][HTML] Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

T Schneider-Hohendorf, LA Gerdes… - Journal of Experimental …, 2022 - rupress.org
Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-
reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T …

[HTML][HTML] Twin study reveals non-heritable immune perturbations in multiple sclerosis

F Ingelfinger, LA Gerdes, V Kavaka, S Krishnarajah… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
underpinned by partially understood genetic risk factors and environmental triggers and …

[HTML][HTML] A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model

A Kendirli, C de la Rosa, KF Lämmle, K Eglseer… - Nature …, 2023 - nature.com
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …

Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment

JB Havla, HL Pellkofer, I Meinl, LA Gerdes… - Archives of …, 2012 - jamanetwork.com
Background The oral sphingosine-1-phosphate receptor modulator fingolimod (FTY720)
was recently approved for the treatment of relapsing-remitting multiple sclerosis. To date …

CTLA4 as immunological checkpoint in the development of multiple sclerosis

LA Gerdes, K Held, E Beltrán, C Berking… - Annals of …, 2016 - Wiley Online Library
We investigated a patient who developed multiple sclerosis (MS) during treatment with the
CTLA4‐blocking antibody ipilimumab for metastatic melanoma. Initially he showed …