User profiles for "author:Kevin V Shianna"
Kevin V ShiannaNew York Genome Center Verified email at nygenome.org Cited by 25166 |
[PDF][PDF] Hepatitis C pharmacogenetics: state of the art in 2010
In 2009, a correlated set of polymorphisms in the region of the interleukin‐28B (IL28B) gene
were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with …
were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with …
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is
the leading cause of cirrhosis in North America. Although the recommended treatment for …
the leading cause of cirrhosis in North America. Although the recommended treatment for …
Common variants conferring risk of schizophrenia
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
Large recurrent microdeletions associated with schizophrenia
H Stefansson, D Rujescu, S Cichon, OPH Pietiläinen… - nature, 2008 - nature.com
Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …
pressure on risk alleles and may explain, in part, why common variants have not been found …
A whole-genome association study of major determinants for host control of HIV-1
Understanding why some people establish and maintain effective control of HIV-1 and
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole …
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole …
[HTML][HTML] HLA-A* 3101 and carbamazepine-induced hypersensitivity reactions in Europeans
M McCormack, A Alfirevic, S Bourgeois… - … England Journal of …, 2011 - Mass Medical Soc
Background Carbamazepine causes various forms of hypersensitivity reactions, ranging
from maculopapular exanthema to severe blistering reactions. The HLA-B* 1502 allele has …
from maculopapular exanthema to severe blistering reactions. The HLA-B* 1502 allele has …
Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
BACKGROUND & AIMS: We recently identified a polymorphism upstream of interleukin (IL)-
28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to …
28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to …
Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
CM Beall, GL Cavalleri, L Deng… - Proceedings of the …, 2010 - National Acad Sciences
By impairing both function and survival, the severe reduction in oxygen availability
associated with high-altitude environments is likely to act as an agent of natural selection …
associated with high-altitude environments is likely to act as an agent of natural selection …
[HTML][HTML] A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
There is considerable variability in the susceptibility of smokers to develop chronic
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …
Clinical application of exome sequencing in undiagnosed genetic conditions
Background There is considerable interest in the use of next-generation sequencing to help
diagnose unidentified genetic conditions, but it is difficult to predict the success rate in a …
diagnose unidentified genetic conditions, but it is difficult to predict the success rate in a …