User profiles for "author:Kevin V Shianna"

Kevin V Shianna

New York Genome Center
Verified email at nygenome.org
Cited by 25166

[PDF][PDF] Hepatitis C pharmacogenetics: state of the art in 2010

NH Afdhal, JG McHutchison, S Zeuzem, A Mangia… - …, 2011 - Wiley Online Library
In 2009, a correlated set of polymorphisms in the region of the interleukin‐28B (IL28B) gene
were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with …

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

D Ge, J Fellay, AJ Thompson, JS Simon, KV Shianna… - Nature, 2009 - nature.com
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is
the leading cause of cirrhosis in North America. Although the recommended treatment for …

Common variants conferring risk of schizophrenia

H Stefansson, RA Ophoff, S Steinberg, OA Andreassen… - Nature, 2009 - nature.com
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Large recurrent microdeletions associated with schizophrenia

H Stefansson, D Rujescu, S Cichon, OPH Pietiläinen… - nature, 2008 - nature.com
Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

A whole-genome association study of major determinants for host control of HIV-1

J Fellay, KV Shianna, D Ge, S Colombo, B Ledergerber… - science, 2007 - science.org
Understanding why some people establish and maintain effective control of HIV-1 and
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole …

[HTML][HTML] HLA-A* 3101 and carbamazepine-induced hypersensitivity reactions in Europeans

M McCormack, A Alfirevic, S Bourgeois… - … England Journal of …, 2011 - Mass Medical Soc
Background Carbamazepine causes various forms of hypersensitivity reactions, ranging
from maculopapular exanthema to severe blistering reactions. The HLA-B* 1502 allele has …

Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus

AJ Thompson, AJ Muir, MS Sulkowski, D Ge, J Fellay… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: We recently identified a polymorphism upstream of interleukin (IL)-
28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to …

Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders

CM Beall, GL Cavalleri, L Deng… - Proceedings of the …, 2010 - National Acad Sciences
By impairing both function and survival, the severe reduction in oxygen availability
associated with high-altitude environments is likely to act as an agent of natural selection …

[HTML][HTML] A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci

SG Pillai, D Ge, G Zhu, X Kong, KV Shianna… - PLoS …, 2009 - journals.plos.org
There is considerable variability in the susceptibility of smokers to develop chronic
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …

Clinical application of exome sequencing in undiagnosed genetic conditions

AC Need, V Shashi, Y Hitomi, K Schoch… - Journal of medical …, 2012 - jmg.bmj.com
Background There is considerable interest in the use of next-generation sequencing to help
diagnose unidentified genetic conditions, but it is difficult to predict the success rate in a …