Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident
LM Morton, DM Karyadi, C Stewart, TI Bogdanova… - Science, 2021 - science.org
INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant
accident exposed millions of individuals in the surrounding region to radioactive …
accident exposed millions of individuals in the surrounding region to radioactive …
[PDF][PDF] HPV16 E7 genetic conservation is critical to carcinogenesis
Although most cervical human papillomavirus type 16 (HPV16) infections become
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …
HPV16 sublineage associations with histology-specific cancer risk using HPV whole-genome sequences in 3200 women
L Mirabello, M Yeager, M Cullen… - JNCI: Journal of the …, 2016 - academic.oup.com
Background: HPV16 is a common sexually transmitted infection although few infections lead
to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only …
to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only …
Germline TP53 Variants and Susceptibility to Osteosarcoma
L Mirabello, M Yeager, PL Mai… - Journal of the …, 2015 - academic.oup.com
The etiologic contribution of germline genetic variation to sporadic osteosarcoma is not well
understood. Osteosarcoma is a sentinel cancer of Li-Fraumeni syndrome (LFS), in which …
understood. Osteosarcoma is a sentinel cancer of Li-Fraumeni syndrome (LFS), in which …
[HTML][HTML] The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma
Metastasis is the leading cause of death in patients with osteosarcoma, the most common
pediatric bone malignancy. We conducted a multistage genome-wide association study of …
pediatric bone malignancy. We conducted a multistage genome-wide association study of …
Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families
L Mirabello, ER Macari, L Jessop… - Blood, The Journal …, 2014 - ashpublications.org
Diamond-Blackfan anemia (DBA) is a cancer-prone inherited bone marrow failure
syndrome. Approximately half of DBA patients have a germ-line mutation in a ribosomal …
syndrome. Approximately half of DBA patients have a germ-line mutation in a ribosomal …
[HTML][HTML] Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection
M Cullen, JF Boland, M Schiffman, X Zhang… - Papillomavirus …, 2015 - Elsevier
For unknown reasons, there is huge variability in risk conferred by different HPV types and,
remarkably, strong differences even between closely related variant lineages within each …
remarkably, strong differences even between closely related variant lineages within each …
Genome analysis of Latin American cervical cancer: frequent activation of the PIK3CA pathway
H Lou, G Villagran, JF Boland, KM Im, S Polo… - Clinical Cancer …, 2015 - AACR
Purpose: Cervical cancer is one of the most common causes of cancer mortality for women
living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 …
living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 …
Novel and known ribosomal causes of Diamond-Blackfan anaemia identified through comprehensive genomic characterisation
L Mirabello, PP Khincha, SR Ellis, N Giri… - Journal of medical …, 2017 - jmg.bmj.com
Background Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure
syndrome (IBMFS) characterised by erythroid hypoplasia. It is associated with congenital …
syndrome (IBMFS) characterised by erythroid hypoplasia. It is associated with congenital …