Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident

LM Morton, DM Karyadi, C Stewart, TI Bogdanova… - Science, 2021 - science.org
INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant
accident exposed millions of individuals in the surrounding region to radioactive …

[PDF][PDF] HPV16 E7 genetic conservation is critical to carcinogenesis

L Mirabello, M Yeager, K Yu, GM Clifford, Y Xiao, B Zhu… - Cell, 2017 - cell.com
Although most cervical human papillomavirus type 16 (HPV16) infections become
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …

HPV16 sublineage associations with histology-specific cancer risk using HPV whole-genome sequences in 3200 women

L Mirabello, M Yeager, M Cullen… - JNCI: Journal of the …, 2016 - academic.oup.com
Background: HPV16 is a common sexually transmitted infection although few infections lead
to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only …

Germline TP53 Variants and Susceptibility to Osteosarcoma

L Mirabello, M Yeager, PL Mai… - Journal of the …, 2015 - academic.oup.com
The etiologic contribution of germline genetic variation to sporadic osteosarcoma is not well
understood. Osteosarcoma is a sentinel cancer of Li-Fraumeni syndrome (LFS), in which …

[HTML][HTML] The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis

L Mirabello, MA Clarke, CW Nelson, M Dean… - 2018 - mdpi.com
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

L Mirabello, R Koster, BS Moriarity, LG Spector… - Cancer discovery, 2015 - AACR
Metastasis is the leading cause of death in patients with osteosarcoma, the most common
pediatric bone malignancy. We conducted a multistage genome-wide association study of …

Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families

L Mirabello, ER Macari, L Jessop… - Blood, The Journal …, 2014 - ashpublications.org
Diamond-Blackfan anemia (DBA) is a cancer-prone inherited bone marrow failure
syndrome. Approximately half of DBA patients have a germ-line mutation in a ribosomal …

[HTML][HTML] Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection

M Cullen, JF Boland, M Schiffman, X Zhang… - Papillomavirus …, 2015 - Elsevier
For unknown reasons, there is huge variability in risk conferred by different HPV types and,
remarkably, strong differences even between closely related variant lineages within each …

Genome analysis of Latin American cervical cancer: frequent activation of the PIK3CA pathway

H Lou, G Villagran, JF Boland, KM Im, S Polo… - Clinical Cancer …, 2015 - AACR
Purpose: Cervical cancer is one of the most common causes of cancer mortality for women
living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 …

Novel and known ribosomal causes of Diamond-Blackfan anaemia identified through comprehensive genomic characterisation

L Mirabello, PP Khincha, SR Ellis, N Giri… - Journal of medical …, 2017 - jmg.bmj.com
Background Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure
syndrome (IBMFS) characterised by erythroid hypoplasia. It is associated with congenital …