Childhood osteogenic sarcoma (OS) is a rare bone cancer occurring primarily in
adolescents. The North American pediatric cooperative groups have performed a series of …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Background: Increased risk of pancreatic cancer has been reported in breast cancer families
carrying BRCA1 and BRCA2 mutations; however, pancreatic cancer risk in mutation …

Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …

The MAD–related (MADR) family of proteins are essential components in the signaling
pathways of serine/threonine kinase receptors for the transforming growth factor β (TGFβ) …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 …

Background Amplification of the human epidermal growth factor receptor type 2 (HER2, also
called HER2/neu) gene and overexpression of its product in breast-cancer cells may be …