Lysosomes are membrane-bound organelles that are found in all mammalian cells and
contain hydrolases and lipases required for protein and membrane degradation. In many …

Cytotoxic T cells (CTL) clear virally infected cells and tumorigenic cells. CTL kill their targets
by releasing very potent cytotoxic proteins stored in preformed secretory organelles termed …

Cytotoxic T lymphocytes (CTLs) destroy their targets by a process involving secretion of
specialized granules. The interactions between CTLs and target can be very brief; …

Cytotoxic T lymphocytes (CTL) rapidly destroy their targets. Here we show that although
target cell death occurs within 5 min of CTL-target cell contact, an immunological synapse …

T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a
minority of patients with cancer. In the majority of these individuals, however, there is a …

MAGE A3, which belongs to the family of cancer-testis antigens, is an attractive target for
adoptive therapy given its reactivation in various tumors and limited expression in normal …

Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing
the contents of specialized secretory lysosomes—termed 'lytic granules'—at the …

Fas ligand (FasL) triggers apoptosis during cytotoxicity mediated by cytotoxic T lymphocytes
and during immune downregulation 1. The ability of T cells and natural killer cells to trigger …

Ubiquitination is a post-translation modification in which ubiquitin chains or single ubiquitin
molecules are appended to target proteins, giving rise to poly-or monoubiquitination …

Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I
molecules are currently being used in cancer patients to elicit stronger T cell responses …