Context Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology
of suicidal behavior andBDNFlevels are decreased in the brain and plasma of suicide …

Background and Purpose—The association between obesity and atherosclerotic disease is
controversial. In the present analysis, we evaluated whether common carotid intima-media …

Background: Noise-induced cochlear epithelium damage can cause hearing loss in
industrial workers. In experimental systems, noise induces the release of free radicals and …

Inherited liver diseases are a group of metabolic and genetic defects that typically cause
early chronic liver involvement. Most are due to a defect of an enzyme/transport protein that …

Cystic fibrosis (CF) is the most frequent lethal genetic disorder among Caucasians. It
depends on alterations of a chloride channel expressed by most epithelial cells and …

Butyrate acts as energy source for intestinal epithelial cells and as key mediator of several
immune processes, modulating gene expression mainly through histone deacetylation …

Background The effect of complex alleles in cystic fibrosis (CF) is poorly defined for the lack
of functional studies. Objectives To describe the genotype–phenotype correlation and the …

The defective mucociliary clearance due to CFTR malfunctioning causes predisposition to
the colonization of pathogens responsible for the recurrent inflammation and rapid …

The last ten years have been characterized by an enormous step forward in the therapy and
management of patients with Cystic Fibrosis (CF), thanks to the development and …

Background Discordant results were reported on the clinical expression of subjects bearing
the D1152H CFTR mutation, and also for the small number of cases reported so far …