Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide,.
Although 58 genomic regions have been associated with CAD thus far,,,,,,, most of the …

Despite intensive efforts using linkage and candidate gene approaches, the genetic etiology
for the majority of families with a multi-generational breast cancer predisposition is unknown …

Background Germline pathogenic variants in SDHB/SDHC/SDHD are the most frequent
causes of inherited phaeochromocytomas/paragangliomas. Insufficient information …

Purpose We assessed the associations between population-based polygenic risk scores
(PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and …

Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These …

Genome-wide association studies (GWAS) have identified more than 170 breast cancer
susceptibility loci. Here we hypothesize that some risk-associated variants might act in non …

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …

Quantifying the genetic correlation between cancers can provide important insights into the
mechanisms driving cancer etiology. Using genome-wide association study summary …