Metformin, an insulin-lowering agent, has been associated with decreased cancer risk in
epidemiologic studies in diabetic patients. We performed a comprehensive literature search …

Background Tamoxifen and raloxifene reduce the risk of breast cancer in women at elevated
risk of disease, but the duration of the effect is unknown. We assessed the effectiveness of …

E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial
polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

Background Aromatase inhibitors effectively prevent breast cancer recurrence and
development of new contralateral tumours in postmenopausal women. We assessed the …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

Importance Limited information about the relationship between specific mutations
inBRCA1orBRCA2 (BRCA1/2) and cancer risk exists. Objective To identify mutation-specific …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

Objectives: To prospectively compare clinical breast examination, mammography,
ultrasonography, and contrast-enhanced magnetic resonance imaging (MRI) in a …