Uridine‐diphosphoglucuronate glucuronosyltransferases (UGTs) are a family of enzymes
that conjugate various endogenous and exogenous compounds with glucuronic acid and …

Beta-cell replacement is considered to be the most promising approach for treatment of type
1 diabetes. Its application on a large scale is hindered by a shortage of cells for …

Background & Aims: The availability of in vitro expandable human hepatocytes would
greatly advance liver-directed cell therapies. Therefore, we examined whether human fetal …

Genetic lesions of bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1
(UGT1A1) completely or partially abolish hepatic bilirubin glucuronidation, causing Crigler …

Scarcity of donor livers is a major obstacle to the general application of hepatocytes for the
development of bioartificial liver assist devices as well as intracorporeal engraftment of …

E ditor—Crigler-Najjar syndrome types 1 and 2 (CN1 and CN2) are inherited as autosomal
recessive conditions and are characterised by severe non-haemolytic unconjugated …

Crigler-Najjar syndrome type 1 (CN-1) is characterized by severe unconjugated
hyperbilirubinemia due to an inherited deficiency of hepatic bilirubin …

Crigler-Najjar syndrome type 1 (CN-1) is a potentially lethal condition, and is the only
inherited disorder of bilirubin metabolism that needs treatment beyond the neonatal period …

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world,
accounting for an estimated 600,000 deaths annually. Although much is known about both …