BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is
characterized by a defective skin barrier function. Recent studies have reported mutations of …

The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …

ISG15 is an interferon (IFN)-α/β–inducible, ubiquitin-like intracellular protein. Its conjugation
to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe …

It has been well established that genetic factors strongly affect susceptibility to asthma and
its associated traits. It is less clear to what extent genetic variation contributes to the ethnic …

Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1)
with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES) …

Germline mutations in CYBB, the human gene encoding the gp91phox subunit of the
phagocyte NADPH oxidase, impair the respiratory burst of all types of phagocytes and result …

BACKGROUND: Asthma is a complex disease characterized by striking ethnic disparities
not explained entirely by environmental, social, cultural, or economic factors. Of the limited …

Objective. Protein citrullination is an important posttranslational modification recognized by
rheumatoid arthritis (RA)–specific autoantibodies. One of the citrullinating enzymes, peptidyl …

Background and Objectives In the last decade, autosomal recessive IL-12Rβ1 deficiency
has been diagnosed in four children with severe tuberculosis from three unrelated families …

BACKGROUND: Both a functional promoter polymorphism in the gene encoding CD14 (C-
260T) and exposure to endotoxin are believed to play key roles in modulating the immune …