User profiles for "author:Antonis C Antoniou"

Prof. Antonis C. Antoniou

Professor of Cancer Risk Prediction, University of Cambridge
Verified email at medschl.cam.ac.uk
Cited by 47575

Improving reporting standards for polygenic scores in risk prediction studies

H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

The future of early cancer detection

RC Fitzgerald, AC Antoniou, L Fruk, N Rosenfeld - Nature medicine, 2022 - nature.com
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …

[HTML][HTML] Polygenes, risk prediction, and targeted prevention of breast cancer

PDP Pharoah, AC Antoniou, DF Easton… - New England Journal …, 2008 - Mass Medical Soc
Background New developments in the search for susceptibility alleles in complex disorders
provide support for the possibility of a polygenic approach to the prevention and treatment of …

Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers

KB Kuchenbaecker, JL Hopper, DR Barnes, KA Phillips… - Jama, 2017 - jamanetwork.com
Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

[HTML][HTML] Breast-Cancer Risk in Families with Mutations in PALB2

AC Antoniou, S Casadei, T Heikkinen… - … England Journal of …, 2014 - Mass Medical Soc
Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …

Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

N Mavaddat, S Peock, D Frost, S Ellis… - JNCI: Journal of the …, 2013 - academic.oup.com
Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …

[HTML][HTML] Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer

E Castro, C Goh, D Olmos, E Saunders… - Journal of Clinical …, 2013 - ncbi.nlm.nih.gov
Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant
Metastasis, and Poor Survival Outcomes in Prostate Cancer - PMC Back to Top Skip to main …

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 …

N Mavaddat, D Barrowdale, IL Andrulis… - … Biomarkers & Prevention, 2012 - AACR
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

KL Bolton, G Chenevix-Trench, C Goh, S Sadetzki… - Jama, 2012 - jamanetwork.com
Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 …

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

RA Eeles, AAA Olama, S Benlloch, EJ Saunders… - Nature …, 2013 - nature.com
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …