Peutz–Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by
the development of characteristic polyps throughout the gastrointestinal tract and …

Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the
development of colorectal cancer, endometrial cancer and various other cancers, and is …

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …

Background: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome,
which is responsible for< 1% of all colorectal cancer (CRC) cases. The syndrome is …

OBJECTIVE: To develop comprehensive clinical practice guidelines for critically ill infants
and children, with specific attention to seven domains of care including pain …

Background & Aims: Hereditary nonpolyposis colorectal carcinoma (HNPCC) is caused by a
mutated mismatch repair (MMR) gene. The aim of our study was to determine the cumulative …

PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant
disease characterized by the clustering of colorectal cancer, endometrial cancer, and …

MSH6 germline mutations 142 nature genetics• volume 23• october 1999 gressive muscular
dystrophy. This mouse will become a useful animal model for studying the …

Instability of microsatellite repeat sequences has been observed in colorectal carcinomas
and in extracolonic malignancies, predominantly endometrial tumours, occurring in the …

Familial colorectal cancer (CRC) accounts for 10–15% of all CRCs. In about 5% of all cases,
CRC is associated with a highly penetrant dominant inherited syndrome. The most common …