Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Background: Mutations in the E-cadherin (CDH1) gene are a well documented cause of
hereditary diffuse gastric cancer (HDGC). Development of evidence based guidelines for …

Genome-wide association studies (GWAS) have previously identified 13 loci associated with
risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify …

We have identified longevity-associated genes in a long-lived Caenorhabditis elegans daf-2
(insulin/IGF receptor) mutant using serial analysis of gene expression (SAGE), a method that …

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is
clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta …

Background: Studies of related individuals have consistently demonstrated notable familial
aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable …

BCL2 is deregulated in diffuse large B-cell lymphoma (DLBCL) by the t (14; 18)
translocation, gene amplification and/or nuclear factor-κB signaling. RNA-seq data have …

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong
heritability. To further understand the genetic susceptibility for CLL and identify common loci …

Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously
identified human leukocyte antigen (HLA) gene variants. To identify additional FL …

Organochlorine chemicals and polychlorinated biphenyls (PCBs) have been suspected as
possible risk factors for non‐Hodgkin lymphoma (NHL). We investigated PCBs and …